Shared Facilities Spotlight: Translational Metabolomics Facility
Post Date: July 30, 2025 | Publish Date:
The Translational Metabolomics Facility (TMF) offers access to state-of-the-art highly sensitive metabolomics and lipidomics technologies, allows users to conduct mixed methods studies in metabolism using a multi-omics approach, and develops custom workflows for the optimal extraction of small metabolites and lipids in a manner compatible with both targeted and untargeted profiling in mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. Its facilitators include experts who are trained in everything from study design to data analysis and interpretation.
The TMF supports basic scientists and clinicians in global metabolomics and lipidomics studies in basic science and clinical settings. It provides analyses using NMR spectroscopy, mass spectrometry and other metabolic function technologies such as the Seahorse XF analyzer.
Over the past decade, the research core has supported more than 200 projects in collaboration with more than 130 principal investigators at Cincinnati Children’s, the University of Cincinnati and several external institutions. It has provided significant support, including preliminary data, that led to the successful awarding of more than 20 federal grants, five foundation grants, five internal grants, two pharmaceutical funding sources, and two successful clinical trials.
“There are very few facilities in the country who offer the services that we do,” said Lindsey Romick, PhD, director of the TMF and associate professor in the Division of Pathology and Laboratory Medicine. “In addition to our top-of-the-line spectrometer, our experts help facilitate data processing, analysis and interpretation and routinely use advanced software such as MNova, R Program and TopSpin.”
Notable research achievements facilitated by the TMF include:
- This study that revealed maternal diet can influence susceptibility of offspring to biliary atresia
- This study on new methods to extract and study immune cells from liver and fat tissue samples taken from obese patients during medical procedures
- This study that looked at how three proteins that help breast cancer spread also change how cancer cells use energy and nutrients
Contact metabolomics@cchmc.org to schedule a time to discuss your project and research goals.
Learn more about our Shared Facilities in this video.
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The Research Horizons blog features news and insights about the latest discoveries and innovations developed by the scientists of Cincinnati Children's. This blog does not provide medical advice, diagnosis, or treatment. Email researchnews@cchmc.org with questions or ideas.
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