Researchers to Give Short Research Talks at 2025 Symposium
Post Date: April 25, 2025 | Publish Date:
In addition to keynote addresses from distinguished experts, a poster session and exhibitor tables from research support services, the Third Annual Research Symposium (May 8, 2025) also will feature Cincinnati Children’s researchers giving short research talks on recent discoveries.
Here is a preview of some of the featured short talks.
Kristin Theobald, MS, LGC, Human Genetics
The CincyKidsSeq Project—Genomic Medicine Optimizes Patient Care
Theobald, a genetic counselor, will talk about CincyKidsSeq, a three-year effort to expand implementation of genomic medicine by gathering genome sequencing data for up to 5,000 participants. The program helps integrate the data into clinical practice, overcome insurance barriers, shorten diagnostic timelines and improve patient management.
Russell Ware, MD, PhD, CBDI: Hematology
Double-Blind, Placebo-Controlled Randomized Controlled Trial of Hydroxyurea for HbSC: Results of the Prospective Identification of Variables as Outcomes for Treatment (PIVOT) Trial
Ware, director of the Division of Hematology, co-executive director of the Cancer and Blood Diseases Institute, and director of the Global Health Center, will share results from the year-long PIVOT trial, which compared hydroxyurea treatment for hemoglobin Sickle Cell disease in children and adults to placebo. Hydroxyurea was well-tolerated and provided significant clinical benefits, including fewer painful vaso-occlusive events and hospitalizations.
Siva Vijayarajan, PhD, Anesthesiology
Next-Generation DNA Methylation Sequencing of Blood Reveals Novel Loci Differentially Methylated in Pediatric Chronic Postsurgical Pain
Vijayarajan, a research fellow, will discuss a study that investigated chronic postsurgical pain (CPSP) in children, focusing on using DNA methylation (DNAm) as a tool to identify epigenetic changes linked to CPSP risk. The findings suggest novel regulatory mechanisms to explore further across diverse populations.
Kaela Boulay, BS, Biostatistics and Epidemiology
Pregnancy Complications Elevate Risk of Cardiovascular Dysfunction in Pre-Menopausal Women
Boulay, a Post-Baccalaureate Research Education (PREP) Scholar, will present a study investigating the link between pregnancy complications and cardiovascular outcomes in pre-menopausal women. The findings suggest that closer post-pregnancy monitoring may help prevent future cardiovascular issues.
Doug Millay, PhD, Heart Institute: Molecular and Cardiovascular Biology
The Muscle Fusogens Go Viral for Gene Delivery
Millay, associate professor, will describe how the muscle-specific fusogens Myomaker and Myomerger can substitute for viral fusogenic proteins to facilitate the entry of enveloped viruses into cells. Researchers used these engineered fusogens to successfully deliver μDystrophin to a mouse model of Duchenne muscular dystrophy, alleviating pathology. The findings suggest that leveraging the properties of myogenic membranes can create a platform for targeted delivery of therapeutic materials to skeletal muscle.
Additional featured short talk presenters include:
Daniel Lucas, PhD, CBDI: Experimental Hematology and Cancer Biology
Anatomical Regulation of Hematopoiesis
Will Zacharias, MD, PhD, Pulmonary Medicine
Defining Epigenetic Regulators of Lung Development and Regeneration
Emily Miraldi, PhD, Immunobiology
Gene Regulatory Network Modeling in Health and Disease
2025 Research Symposium
Thursday, May 8, 2025
9 am – 5 pm
Watch the morning and afternoon presentations here.
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The Research Horizons blog features news and insights about the latest discoveries and innovations developed by the scientists of Cincinnati Children's. This blog does not provide medical advice, diagnosis, or treatment.
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