Research Horizons


Vaccine Strategies to Protect More Newborns from Fatal Infections

Nearly half of under-age-5 mortality occurs in the first few weeks after birth,  and a large fraction of these deaths are caused by infection.

Vaccinating expecting mothers has proven effective against certain pathogens, including rubella and tetanus. So why hasn’t this approach been developed for other microbes that cause infection in babies?

A review article in Science, published online May 8, 2020, explores this question and other approaches to more broadly stimulate the immune system in newborn babies. The article is co-authored by Sing Sing Way, MD, PhD, an infectious disease physician-scientist at Cincinnati Children’s.

“Enhanced protection will likely require previously unexplored strategies that combine vaccination of mothers and their newborns to simultaneously stimulate pathogen-agonistic and pathogen-specific immunity,” the co-authors write.

Publication Information
Original title: Vaccination Strategies to Enhance Immunity in Neonates
Published in: Science
Publish date: May 8, 2020
Read the Review

Research By

Sing Sing Way, MD, PhD
Pauline and Lawson Reed Chair, Division of Infectious Diseases
Dr. Way supervises an active basic research laboratory that uses basic immunological approaches to investigate ways to boost host defense and protection against infection.