Sleep Apnea Model Reveals Round-the-Clock Gene Function Disruptions
Research By: Bala Koritala, PhD | David Smith, MD, PhD
Post Date: May 30, 2023 | Publish Date: May 30, 2023
When obstructive sleep apnea reduces blood oxygen levels, the disruptions that follow go far beyond a poor night’s sleep.
Using a mouse model, experts at Cincinnati Children’s led by Bala Koritala, PhD, and David Smith, MD, PhD, have detailed a wide range of changes in circadian activity involving genes located in many tissues.
The co-authors say their findings could be used to develop improved diagnostic tests that may provide earlier warning of sleep apnea-related health risks.
Details were published May 30, 2023, in PLOS Biology.
|Original title:||Obstructive sleep apnea in a mouse model is associated with tissue-specific transcriptomic changes in circadian rhythmicity and mean 24-hour gene expression|
|Published in:||PLOS Biology|
|Publish date:||May 30, 2023|
We all have an internal clock that prepares the body to exercise, eat, digest and sleep at specific times of the day. In my lab, we are studying how disruption of this circadian clock occurs in the setting of obstructive sleep apnea.