Post Date: January 7, 2022
Post written by Shawna Hottinger, MS, ELS.
The next wave of research for eosinophilic gastrointestinal diseases (EGID) will focus on under-studied conditions that affect the body beyond the esophagus, according to a recently published article by Marc Rothenberg, MD, PhD, and colleagues.
The article, entitled “Impressions and Aspirations from the FDA GREAT VI Workshop on Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic Esophagitis and Perspectives for Progress in the Field,” appears online in the Journal of Allergy and Clinical Immunology. It recaps the findings of a scientific workshop hosted by the U.S. Food and Drug Administration (FDA) on July 21, 2021.
Eosinophilic gastrointestinal diseases (EGID) are rare allergic conditions of the gastrointestinal tract, with eosinophilic esophagitis (EoE) being the most common and studied. Importantly, diagnosis of EGID is often delayed. The workshop discussed the disease characteristics, natural history, and endpoints to assess treatment benefit in patients with EGID beyond EoE, referred to as non-EoE EGID.
(To view a meeting recording, visit https://www.fda.gov/drugs/news-events-human-drugs/gastroenterology-regulatory-endpoints-and-advancement-therapeutics-vi-great-vi-workshop-eosinophilic )
Notably, non-EoE EGIDs, such as eosinophilic gastritis, eosinophilic enteritis, and eosinophilic colitis, are understudied relative to EoE. The workshop included contributions from researchers in allergy, immunology, epidemiology, gastroenterology, pathology; clinicians serving adults and children; and stakeholder representatives for the FDA, industry, and patient advocacy groups.
Key points from the meeting include:
Rothenberg and colleagues stated that several next steps that would benefit the non-EoE EGID field, including:
Learn more about ongoing research at the Rothenberg CURED Lab
The Research Horizons blog features news and insights about the latest discoveries and innovations developed by the scientists of Cincinnati Children's. This blog does not provide medical advice, diagnosis, or treatment.