2019 Research Annual Report

2019 Research Annual Report

This year’s report includes 7 premier accomplishments and top publications of the year for more than 50 research divisions.

“Spanning the full spectrum of discovery—basic exploration of biological mechanisms, translation to patients, and improvement of community health—our achievements in 2019 have surpassed all previous benchmarks.”

Margaret K. Hostetter, MD

B.K. Rachford Professor
Chair, Department of Pediatrics; Director, Cincinnati Children’s Research Foundation; Chief Medical Officer

 

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From left: Russell Ware, MD, PhD, and co-author Patrick McGann, MD, played key roles in the REACH study, which demonstrated the life-saving potential of hydroxyurea.

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Stephen Trisno, shown, James Wells, PhD, and colleagues extended a strong track record of organoid advances at Cincinnati Childrens with success at developing the first human esophagus organoid.

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So-called “good bugs” failed to show any value at fighting off “stomach bugs,” according to a study led by David Schnadower, MD, Senior Academic Director, Division of Emergency Medicine.

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Data from the 29-center PROTECT study, led by co-principal investigator Lee (Ted) Denson, MD, suggests a fundamental shift in treatment approach. for children coping with ulcerative colitis.

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From left: First author, Marc Ruben, PhD; and senior author John Hogenesch, PhD; both of the Division of Human Genetics, led a breakthrough study that catalogs more than 900 cycling genes that encode proteins for transporting or metabolizing drugs, or are themselves drug targets.

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A far-reaching study led by Theresa Alenghat, VMD, PhD, reports that targeting the intestinal enzyme HDAC3 may initiate metabolic improvement and promote weight
loss.

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In mice, using light to influence the opsin 5-dopamine pathway positively affects vascular development in the eye, according to a study led by Minh-Thanh Nguyen, PhD, and Richard Lang, PhD, Director of the Visual Systems Group.