Metformin Helps Control Weight Gain From Certain Bipolar Medications
Post Date: November 13, 2025 | Publish Date: Oct. 28, 2025
The MOBILITY clinical trial–the largest study of its kind–explored a common side effect from prescribing second-generation antipsychotics (SGAs)
Results from the largest and longest study of its kind found the drug metformin plus a healthy lifestyle can help manage weight gain in youth taking SGA medications to treat bipolar disorder and should be adopted as a standard of care treatment.
Led by scientists at the University of Cincinnati and Cincinnati Children’s, data from the MOBILITY trial were published online in November 2025 in The Lancet Psychiatry and will appear in the journal’s December issue.
“This embodies everything good about Children’s and UC’s collaboration and clinic to research evidence-based practices,” says co-author Suzanne Sampang, MD, Interim Division Director, Child and Adolescent Psychiatry at Cincinnati Children’s.
Read the full UC announcement
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The Research Horizons blog features news and insights about the latest discoveries and innovations developed by the scientists of Cincinnati Children's. This blog does not provide medical advice, diagnosis, or treatment. Email researchnews@cchmc.org with questions or ideas.
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