Research Horizons


ICYMI…Research News in ADHD, Puberty Onset, Peanut Allergy, and More

While the world has focused largely on the COVID-19 pandemic, the pipeline of research to improve child health continues to flow.

Here are several highly-shared findings published since March 1, 2020, that you might have missed:

The Lancet Digital Health: A novel digital intervention for actively reducing severity of paediatric ADHD (STARS-ADHD): a randomised controlled trial.

This study, sponsored by the software maker Akili Interactive Labs, was co-authored by Jeffery Epstein, PhD, Director of the Center for ADHD at Cincinnati Children’s.


JAMA Pediatrics: Worldwide Secular Trends in Age at Pubertal Onset Assessed by Breast Development Among Girls

This report, co-authored by adolescent medicine expert Frank Biro, MD, reports that the mean age of puberty onset has decreased by about a year since 1977.

Science Immunology: Origins and clonal convergence of gastrointestinal IgE+ B cells in human peanut allergy

This study, led by researchers at Stanford University, included co-author Krishna Roskin, PhD, Division of Biomedical Informatics.

JAMA Internal Medicine: Post–Acute Kidney Injury Proteinuria and Subsequent Kidney Disease Progression

The study reflects the findings of the multi-institutional ASSESS-AKI research team. Co-authors included Prasad Devarajan, MD, Director, Division of Nephrology and Hypertension at Cincinnati Children’s, and a long-time leader in AKI research.


Clinical Journal of The American Society of Nephrology: Prognostic Value of Ambulatory Blood Pressure Load in Pediatric CKD

This chronic kidney disease study was co-authored by Mark Mitsnefes, MD, MS, Division of Nephrology and Hypertension at Cincinnati Children’s.

Pediatrics: Antibiotic Use and Outcomes in Children in the Emergency Department With Suspected Pneumonia

This report was co-authored by a team of experts at Cincinnati Children’s, including Richard Ruddy, MD, Division of Emergency Medicine, and Samir Shah, MD, Director, Division of Hospital Medicine at Cincinnati Children’s.

Journal of Virology: A Bivalent, Spherical Virus-Like Particle Vaccine Enhances Breadth of Immune Responses against Pathogenic Ebola Viruses

This breakthrough in Ebola vaccine research was led by first author Karnail Singh, PhD, and Paul Spearman, MD, Director, Division of Infectious Diseases.

Learning Health Systems: Networked health care: Rethinking value creation in learning health care systems

This multi-section technical report was co-authored by Michael Seid, PhD, Director, Health Outcomes and Quality Care Research, Division of Pulmonary Medicine, and (corresponding author) Peter Margolis, MD, PhD, Co-Director, James M. Anderson Center for Health Systems Excellence.