CRISPR-Edited Mice Help Reveal Potential Nanoparticle Treatment for ACDMPV
Research By: Vladimir Kalinichenko, MD, PhD
Post Date: August 12, 2019 | Publish Date: June 14, 2019
Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins (ACDMPV) is a very rare congenital respiratory disorder that usually proves fatal to infants within a month of birth.
But new findings from researchers at Cincinnati Children’s suggest a potential step forward toward longer survival.
Scientists here used CRISPR/Cas9 to generate mice that faithfully mimic the disorder. The new mouse model allowed researchers to pinpoint the disorder’s cause and identify a potential nanoparticle-based treatment.
Findings appear in the American Journal of Respiratory and Critical Care Medicine.
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| Original title: | The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia |
| Published in: | American Journal of Respiratory and Critical Care Medicine |
| Publish date: | June 14, 2019 |
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The Research Horizons blog features news and insights about the latest discoveries and innovations developed by the scientists of Cincinnati Children's. This blog does not provide medical advice, diagnosis, or treatment.
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