Research Horizons

Search

CRISPR-Edited Mice Help Reveal Potential Nanoparticle Treatment for ACDMPV

  • Bluesky
This confocal microscopic image shows FOXF1 deficient fetal lung cells from mice. FOXF1 deficiency inhibits the normal development and proliferation of lung cells and helps cause a fatal disease in infants called Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins.

Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins (ACDMPV) is a very rare congenital respiratory disorder that usually proves fatal to infants within a month of birth.

But new findings from researchers at Cincinnati Children’s suggest a potential step forward toward longer survival.

Scientists here used CRISPR/Cas9 to generate mice that faithfully mimic the disorder. The new mouse model allowed researchers to pinpoint the disorder’s cause and identify a potential nanoparticle-based treatment.

Findings appear in the  American Journal of Respiratory and Critical Care Medicine.

Read more

Publication Information
Original title: The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia
Published in: American Journal of Respiratory and Critical Care Medicine
Publish date: June 14, 2019
Read the study

Research By

kalinichenko-4x3-1024x768-e1623428524850.jpg
Vladimir Kalinichenko, MD, PhD
Division of Pulmonary Biology
The Kalinichenko lab investigates novel transcriptional mechanisms critical for embryonic lung development, lung injury/repair and lung carcinogenesis.
  • Bluesky