Research Horizons
Can a “Prodrug” Defeat Treatment-Resistant SHH-Medulloblastoma?
Research By Q. Richard Lu, PhD
Post Date: August 29, 2019 | Publish Date: Aug. 29, 2019
Single-cell transcriptomics helped scientists at Cincinnati Children’s find a potential treatment for aggressive SHH-medulloblastoma, like the tumor shown in this MRI image.
A study published Aug. 29, 2019, in Cancer Cell used new forms of technology to find potential new ways to treat a deadly form of brain cancer.
Existing small-molecule inhibitors can target the oncogenic cascade pathways that cause SHH-medullablastoma tumor initiation and recurrence, says Q. Richard Lu, PhD, senior author and scientific director of the Brain Tumor Center at Cincinnati Children’s.
Read more about how immature oligodendrocyte progenitor cells in the brain—which can assume stem-cell-like qualities—grow out of control to form medulloblastoma tumors and about a “prodrug” concept that might stop the cascade.
Publication Information
| Original Title: | Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse |
|---|---|
| Published in: | Cancer Cell |
| Publish date: | Aug. 29, 2019 |
Research By
Q. Richard Lu, PhD
Scientific Director, Brain Tumor Center
A major focus of our lab research is to elucidate the transcriptional, posttranscriptional, epigenetic and signaling regulatory networks that govern glial progenitor fate specification, myelination and glioma formation.
Research Areas
- > Asthma and Allergy
- > Autoimmune Disorders
- > Big Data and Analytics
- > Cancer
- > Community Health
- > Diabetes and Obesity
- > Digestive System
- > Emergency and Critical Care
- > Genomics and Development
- > Health Inequities
- > Heart and Lung
- > Imaging Sciences
- > Infectious Diseases and Vaccines
- > Mind Brain Behavior
- > Organoids
- > Ortho, Sports Med and Rehab
- > Perinatal
- > Quality and Safety
- > Rare Diseases
- > Research Annual Report 2021
- > Sensory Systems
- > Surgical Science
- > Tools for Science
Latest Posts
About this blog
The Research Horizons blog features news and insights about the latest discoveries and innovations developed by the scientists of Cincinnati Children's. This blog does not provide medical advice, diagnosis, or treatment.
Blog Archive
- > May 2022
- > April 2022
- > March 2022
- > February 2022
- > January 2022
- > December 2021
- > November 2021
- > October 2021
- > September 2021
- > August 2021
- > July 2021
- > June 2021
- > May 2021
- > April 2021
- > March 2021
- > February 2021
- > January 2021
- > December 2020
- > November 2020
- > October 2020
- > September 2020
- > August 2020
- > July 2020
- > June 2020
- > May 2020
- > April 2020
- > March 2020
- > February 2020
- > January 2020
- > December 2019
- > November 2019
- > October 2019
- > September 2019
- > August 2019
- > July 2019
- > June 2019