More Data Emerges About the Role ACE2 Plays in COVID-19
The drug infliximab, which is often used to manage inflammation among people with inflammatory bowel disease (IBD), may also help aid recovery for certain people infected by COVID-19, according to a new study published online Nov. 5, 2020, in the journal Gastroenterology.
Normally, angiotensin-converting enzyme 2 (ACE2) activates a hormone that helps regulate blood pressure. However, in the gastrointestinal tract, ACE2 levels influence inflammation that can aggravate IBD symptoms.
In COVID-19 infections, the SARS-CoV-2 virus binds to ACE2 and uses it to invade cells and spread the virus. Although noted early on for its affects on lung tissue, the novel coronavirus also can cause potentially severe gastrointestinal symptoms.
In the new study, co-authors report that treatment with infliximab normalized ACE2 levels in the GI tract among people with IBD, which suggests that managing ACE2 levels for COVID-19 patients could help control inflammation damage caused by the virus.
The study’s senior author was Cedars-Sinai IBD expert Dermot McGovern, MD, PhD. Lee Denson, MD, Director, Schubert-Martin Inflammatory Bowel Disease Center at Cincinnati Children’s co-authored the study.
“Our results may provide a link between ACE2 levels and demographic features such as increasing age and body mass index which have been associated with worse COVID-19 outcomes, and suppport novel anti-inflammatory therapies such as JAK1/2 inhibitors which are currently being tested in clinical trials,” Denson says.
Other collaborating institutions included the Broad Institute of MIT and Harvard, Emory University School of Medicine, Children’s Healthcare of Atlanta, the Cleveland Clinic; and Janssen Research and Development LLC.
Read the study in Gastroenterology