Research Horizons


Tool Identifies Autism Risk Early in Patients with Tuberous Sclerosis Complex

A tool that diagnoses autism spectrum disorders (ASD) identifies autism risk in patients with tuberous sclerosis complex (TSC) earlier than ever before possible.

TSC causes malformations and tumors in the brain and other vital organs. Children with TSC are more likely to have ASD.

A study published online in Pediatric Neurology evaluated 79 children up to 24 months old, all of whom had TSC. Researchers administered the Autism Observation Scale for Infants at 12 months of age, examining activities including visual tracking and response to facial emotion. They followed this with the Autism Diagnostic Observation Schedule-2 at 24 months.

Infants at greater risk of ASD scored significantly higher at 12 months than the non-ASD group, says Jamie Capal, MD, lead author, Division of Neurology, “demonstrating that it is a useful clinical tool in determining which infants with TSC are at increased risk of developing ASD.”

Publication Information
Original title: Utility of the Autism Observation Scale for Infants in Early Identification of Autism in Tuberous Sclerosis Complex
Published in: Pediatric Neurology
Publish date: October 2017
Read the study

Research By

Jamie Capal, MD
Neurodevelopmental and Autism Specialist, Division of Neurology
Dr. Capal’s clinical and research interests focus on children with autism spectrum disorders and related neurodevelopmental conditions.