PYY Hormone Reverses Congenital Malabsorption in Mice

Research By Heather McCauley, PhD

Post Date: September 22, 2020 | Publish Date: Sept. 22, 2020


This image of a human intestinal organoid shows enteroendocrine cells (red) embedded within the intestinal cells of the HIO (green).

The hormone peptide YY, also called PYY, can reverse congenital malabsorption in mice, according to new findings in Nature Communications.

With a single PYY injection per day, 80% of the mice survived despite a congenital lack nutrient absorption in their intestines. Normally, only 20% to 30% survive.

The findings, led by Heather McCauley, PhD, Division of Developmental Biology, indicates PYY may eventually become a therapy for human infants born short-gut syndrome, and possibly others who experience malnutrition, or develop intestinal infections.

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Publication Information

Original Title:Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport
Published in:Nature Communications
Publish date:Sept. 22, 2020

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Research By

  • Heather McCauley, PhD

    Heather McCauley, PhD

    Division of Developmental Biology

    Dr. McCauley is using mouse models and PSC-derived human intestinal organoids to investigate how enteroendocrine cells within the GI tract regulate nutrient absorption and intestinal function.