Research Horizons


PYY Hormone Reverses Congenital Malabsorption in Mice

The hormone peptide YY, also called PYY, can reverse congenital malabsorption in mice, according to new findings in Nature Communications.

With a single PYY injection per day, 80% of the mice survived despite a congenital lack nutrient absorption in their intestines. Normally, only 20% to 30% survive.

The findings, led by Heather McCauley, PhD, Division of Developmental Biology, indicates PYY may eventually become a therapy for human infants born short-gut syndrome, and possibly others who experience malnutrition, or develop intestinal infections.

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Publication Information
Original title: Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport
Published in: Nature Communications
Publish date: Sept. 22, 2020
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Research By

Heather McCauley, PhD
Division of Developmental Biology
Dr. McCauley is using mouse models and PSC-derived human intestinal organoids to investigate how enteroendocrine cells within the GI tract regulate nutrient absorption and intestinal function.