PYY Hormone Reverses Congenital Malabsorption in Mice
Research By: Heather McCauley, PhD
Post Date: September 22, 2020 | Publish Date: Sept. 22, 2020
The hormone peptide YY, also called PYY, can reverse congenital malabsorption in mice, according to new findings in Nature Communications.
With a single PYY injection per day, 80% of the mice survived despite a congenital lack nutrient absorption in their intestines. Normally, only 20% to 30% survive.
The findings, led by Heather McCauley, PhD, Division of Developmental Biology, indicates PYY may eventually become a therapy for human infants born short-gut syndrome, and possibly others who experience malnutrition, or develop intestinal infections.
Read the media release
|Original title:||Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport|
|Published in:||Nature Communications|
|Publish date:||Sept. 22, 2020|
Heather McCauley, PhD
Division of Developmental Biology
Dr. McCauley is using mouse models and PSC-derived human intestinal organoids to investigate how enteroendocrine cells within the GI tract regulate nutrient absorption and intestinal function.