PERSEVERE Passes Early Accuracy Test

Research By Hector Wong, MD

Post Date: November 13, 2019 | Publish Date: Nov. 13, 2019


Staff care for a baby in the Pediatric Intensive Care Unit (PICU) at Cincinnati Children’s Hospital Medical Center. Fragile young children in critical care can be prone to sepsis, a medical complication that sends infection through the body. A study in Science Translational Medicine reports that Cincinnati Children’s researchers developed and successfully tested a new rapid blood assay that accurately predicts which patients are at low, medium or high risk for death from sepsis.

Researchers at Cincinnati Children’s have successfully tested the new PERSEVERE rapid blood assay, which uses just five biomarkers to accurately predict whether critically ill children receiving intensive care are at low, medium or high risk for death from sepsis.

Detailed findings were published online Nov. 13, 2019, in Science Translational Medicine.

Beyond data from mouse models, the research team led by Hector Wong, MD, Director of Critical Care Medicine at Cincinnati Children’s, obtained permission from patient families and the  Institutional Review Boards of participating institutions, to test blood samples from 461 children receiving intensive care.

The predict model proved as accurate for the children as it had for the mice. However, since PERSEVERE is not yet approved for clinical use, it was not used to inform or influence patient care decisions. It was tested only for accuracy and potential future use.

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Publication Information

Original Title:Prospective clinical testing and experimental validation of the Pediatric Sepsis Biomarker Risk Model
Published in:Science Translational Medicine
Publish date:Nov. 13, 2019

Read the study

Research By

  • Hector Wong, MD

    Hector Wong, MD

    Director, Division of Critical Care Medicine

    The Wong Laboratory is dedicated to sepsis, severe sepsis and septic shock, syndromes that arise in response to serious infections.

About this blog

The Research Horizons blog features news and insights about the latest discoveries and innovations developed by the scientists of Cincinnati Children's. This blog does not provide medical advice, diagnosis, or treatment.