Licensing Innovation to Improve Pediatric Acute Kidney Injury Care: The Renal Angina Index
Post Date: March 14, 2025 | Publish Date:
Cincinnati Children’s has licensed the Renal Angina Index (RAI) application, a novel tool for predicting acute kidney injury in critically ill children, to RAIDAR Health LLC to bring this life-saving technology to market. Acute kidney injury affects up to one-third of pediatric intensive care unit patients and can lead to severe complications without timely intervention. The RAI uses a scoring system that combines clinical risk factors with kidney injury indicators to predict severe acute kidney injury within 72 hours of admission, enabling earlier therapeutic decisions that may improve patient outcomes and cost of care through pediatric ICU length of stay reduction.
Developed by Stuart Goldstein, MD, professor and director of the Cincinnati Children’s Center for Acute Care Nephrology, the RAI calculates a risk score by evaluating factors such as transplant history, intubation status, and changes in kidney function or fluid overload. It helps to identify patients at high risk of severe acute kidney injury, guiding clinicians toward proactive interventions like early continuous renal replacement therapy. Preliminary studies show that RAI helps reduce intensive care length of stay and enhances survival rates by providing clinicians with a standardized and predictive decision-making tool.
Through the licensing agreement with RAIDAR Health, the RAI has been integrated into a clinical decision support platform that empowers healthcare professionals to implement this innovative technology in real-world settings. This collaboration underscores Cincinnati Children’s commitment to translating research breakthroughs into practical applications that improve patient care.
“Licensing our RAI application to RAIDAR Health will allow for dissemination of the acute kidney injury risk stratification across multiple pediatric institutions at a more rapid pace than what would be possible if each center developed their own RAI application,” Goldstein said. “The ultimate vision is for pediatric hospitals to partner with RAIDAR Health to provide real-time risk stratification for prospective multi-center platform trials to rapidly assess interventions and practices to improve outcomes for critically ill children with, or at-risk for acute kidney injury.”
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The Research Horizons blog features news and insights about the latest discoveries and innovations developed by the scientists of Cincinnati Children's. This blog does not provide medical advice, diagnosis, or treatment.
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