Healthy T Cell Formation Depends on Transcription Factor AP-1 to Open Chromatin

Research By Artem Barski, PhD,

Post Date: October 25, 2019 | Publish Date: Oct. 25, 2019


New findings in the Journal of Experimental Medicine, show locations of open chromatin in T cells where transcription factors bind to help the immune cells develop. (TOP). Heat maps show the presence of the molecule H3K4me2 in the T helper cells of asthma patients and healthy control patients. (BOTTOM)

A Cincinnati Children’s research team has identified a gene and a family of proteins critical to the formation of T cells, which could help improve targeted therapies for immune-related diseases like multiple sclerosis and inflammatory bowel syndrome.

Details were published online Oct. 25, 2019, in the Journal of Experimental Medicine.

“Our goal is to use this mechanistic knowledge to eventually develop protective vaccines, anti-cancer immune therapies or reduce pathologic immune responses like asthma, allergies, and autoimmunity,” says Artem Barski, PhD, lead study investigator and scientist in the divisions of Allergy and Immunology and Human Genetics.

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Publication Information

Original Title:AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation
Published in:Journal of Experimental Medicine
Publish date:Oct. 25, 2019

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The Research Horizons blog features news and insights about the latest discoveries and innovations developed by the scientists of Cincinnati Children's. This blog does not provide medical advice, diagnosis, or treatment.