Research Horizons
- Home
- Findings
- Genomics and Development
- Healthy T Cell Formation Depends on Transcription Factor AP-1 to Open Chromatin
Healthy T Cell Formation Depends on Transcription Factor AP-1 to Open Chromatin
Research By Artem Barski, PhD,
Post Date: October 25, 2019 | Publish Date: Oct. 25, 2019
New findings in the Journal of Experimental Medicine, show locations of open chromatin in T cells where transcription factors bind to help the immune cells develop. (TOP). Heat maps show the presence of the molecule H3K4me2 in the T helper cells of asthma patients and healthy control patients. (BOTTOM)
A Cincinnati Children’s research team has identified a gene and a family of proteins critical to the formation of T cells, which could help improve targeted therapies for immune-related diseases like multiple sclerosis and inflammatory bowel syndrome.
Details were published online Oct. 25, 2019, in the Journal of Experimental Medicine.
“Our goal is to use this mechanistic knowledge to eventually develop protective vaccines, anti-cancer immune therapies or reduce pathologic immune responses like asthma, allergies, and autoimmunity,” says Artem Barski, PhD, lead study investigator and scientist in the divisions of Allergy and Immunology and Human Genetics.
Read More
Publication Information
| Original Title: | AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation |
|---|---|
| Published in: | Journal of Experimental Medicine |
| Publish date: | Oct. 25, 2019 |
Research By
Artem Barski, PhD
Director, Epigenomics Data Analysis Core
Artem Barski, PhD, is interested in epigenomics and transcriptional regulation of gene expression.
Research Areas
- > Asthma and Allergy
- > Autoimmune Disorders
- > Big Data and Analytics
- > Cancer
- > Community Health
- > Diabetes and Obesity
- > Digestive System
- > Emergency and Critical Care
- > Genomics and Development
- > Health Inequities
- > Heart and Lung
- > Imaging Sciences
- > Infectious Diseases and Vaccines
- > Mind Brain Behavior
- > Organoids
- > Ortho, Sports Med and Rehab
- > Perinatal
- > Quality and Safety
- > Rare Diseases
- > Research Annual Report 2021
- > Sensory Systems
- > Surgical Science
- > Tools for Science
Latest Posts
About this blog
The Research Horizons blog features news and insights about the latest discoveries and innovations developed by the scientists of Cincinnati Children's. This blog does not provide medical advice, diagnosis, or treatment.
Blog Archive
- > June 2022
- > May 2022
- > April 2022
- > March 2022
- > February 2022
- > January 2022
- > December 2021
- > November 2021
- > October 2021
- > September 2021
- > August 2021
- > July 2021
- > June 2021
- > May 2021
- > April 2021
- > March 2021
- > February 2021
- > January 2021
- > December 2020
- > November 2020
- > October 2020
- > September 2020
- > August 2020
- > July 2020
- > June 2020
- > May 2020
- > April 2020
- > March 2020
- > February 2020
- > January 2020
- > December 2019
- > November 2019
- > October 2019
- > September 2019
- > August 2019
- > July 2019
- > June 2019