Research Horizons


Healthy T Cell Formation Depends on Transcription Factor AP-1 to Open Chromatin

A Cincinnati Children’s research team has identified a gene and a family of proteins critical to the formation of T cells, which could help improve targeted therapies for immune-related diseases like multiple sclerosis and inflammatory bowel syndrome.

Details were published online Oct. 25, 2019, in the Journal of Experimental Medicine.

“Our goal is to use this mechanistic knowledge to eventually develop protective vaccines, anti-cancer immune therapies or reduce pathologic immune responses like asthma, allergies, and autoimmunity,” says Artem Barski, PhD, lead study investigator and scientist in the divisions of Allergy and Immunology and Human Genetics.

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Publication Information
Original title: AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation
Published in: Journal of Experimental Medicine
Publish date: Oct. 25, 2019
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Research By

Artem Barski, PhD
Director, Epigenomics Data Analysis Core
Artem Barski, PhD, is interested in epigenomics and transcriptional regulation of gene expression.