Research Horizons


EoE Research Selected as ‘Editor’s Choice’ in JACI

A study led by experts at Cincinnati Children’s that explores whether infants diagnosed with eosinophilic esophagitis (EoE) represent a severe endotype of the disease was named an “Editor’s Choice” by the Journal of Allergy and Clinical Immunology.

The paper’s co-authors include first author John Lyles, MD, a former fellow in the Division of Gastroenterology, Hepatology and Nutrition; and corresponding author Marc Rothenberg, MD, PhD, Director, Division of Allergy and Immunology.

Contributing co-authors include Tetsuo Shoda, PhD, and Michael Trimarchi, PhD, Division of Allergy and Immunology; Margaret Collins, MD, Division of Pathology and Laboratory Medicine; Lisa Martin, PhD, and Hua He, MS, Division of Human Genetics;  Vincent Mukkada, MD, Division of Gastroenterology, Hepatology and Nutrition; and Leah Kottyan, PhD, Center for Autoimmune Genomics and Etiology.

The paper reports that Cesarean delivery and CAPN14 genetic variation likely promote earlier disease development among very early-onset cases (V-EoE). However, very early-onset cases responded just as well to dietary intervention as later-onset cases.

“Contrary to our hypothesis that V-EoE would represent an endotype with worse prognosis, these data demonstrate that V-EoE responds well to standard therapy,” the co-authors wrote.

Rothenberg adds, “In this study, we show that eosinophilic esophagitis (EoE) in very young infants is a common presentation. We also identify the relative strong role for specific genetic and environmental risk factors. These data not only uncover scientific understanding of EoE, but also have a clinical message for doctors and parents…be on the lookout for EoE even in young babies.”