EoE Research Selected as ‘Editor’s Choice’ in JACI

Post Date: January 13, 2021

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Source: JACI and Cincinnati Children’s

A study led by experts at Cincinnati Children’s that explores whether infants diagnosed with eosinophilic esophagitis (EoE) represent a severe endotype of the disease was named an “Editor’s Choice” by the Journal of Allergy and Clinical Immunology.

The paper’s co-authors include first author John Lyles, MD, a former fellow in the Division of Gastroenterology, Hepatology and Nutrition; and corresponding author Marc Rothenberg, MD, PhD, Director, Division of Allergy and Immunology.

Contributing co-authors include Tetsuo Shoda, PhD, and Michael Trimarchi, PhD, Division of Allergy and Immunology; Margaret Collins, MD, Division of Pathology and Laboratory Medicine; Lisa Martin, PhD, and Hua He, MS, Division of Human Genetics;  Vincent Mukkada, MD, Division of Gastroenterology, Hepatology and Nutrition; and Leah Kottyan, PhD, Center for Autoimmune Genomics and Etiology.

The paper reports that Cesarean delivery and CAPN14 genetic variation likely promote earlier disease development among very early-onset cases (V-EoE). However, very early-onset cases responded just as well to dietary intervention as later-onset cases.

“Contrary to our hypothesis that V-EoE would represent an endotype with worse prognosis, these data demonstrate that V-EoE responds well to standard therapy,” the co-authors wrote.

Rothenberg adds, “In this study, we show that eosinophilic esophagitis (EoE) in very young infants is a common presentation. We also identify the relative strong role for specific genetic and environmental risk factors. These data not only uncover scientific understanding of EoE, but also have a clinical message for doctors and parents…be on the lookout for EoE even in young babies.”

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The Research Horizons blog features news and insights about the latest discoveries and innovations developed by the scientists of Cincinnati Children's. This blog does not provide medical advice, diagnosis, or treatment.