Research By John Hogenesch, PhD
Post Date: August 12, 2019 | Publish Date: Aug. 9, 2019
This blog post reflects a series of Tweets written by John Hogenesch, PhD. (@jbhclock)
Chronotherapy, or timing therapies according to the time of day, has a 50+ year history.
Since then, hundreds of papers have come out examining time of dosage of many different classes of drugs, e.g. drugs to treat asthma, hypertension, arthritis, cancer, etc. In fact, last year there were 15 reviews on the subject. Despite this, there’s been little change to clinical practice.
To gain insight into successful strategies, our lab @CincyChildrens and Garret FitzGerald @PennMedicine studied the results of 106 human trials that evaluated time-of-administration of drugs. We focused on studies where more than one time of day was tested in the same study.
These are some of the most commonly taken drugs on Earth. Dosing time matters.
Many of these trials were underpowered. We need to go bigger. Will EMR mining play a role in some of these indications?
We also need to account for circadian time, rather than the time on the wall. Recent work from our lab, but also Derk-Jan Dijk, @jakehughey, @AchimKramer, @AlladaSleep, and others are operationalizing circadian biomarkers.
|Original Title:||Dosing Time Matters|
|Publish date:||Aug. 9, 2019|
The Research Horizons blog features news and insights about the latest discoveries and innovations developed by the scientists of Cincinnati Children's. This blog does not provide medical advice, diagnosis, or treatment.