Research Horizons


CuSTOM Organoid Research Evolving From Tool to Treatment

Two scientists at Cincinnati Children’s describe the fast-evolving field of organoid medicine as “today’s research tool, tomorrow’s organ transplant solution.”

A special feature published March 14, 2024, in Science explores advances made by the Cincinnati Children’s Center for Stem Cell and Organoid Medicine (CuSTOM). The article features organoid experts Takanori Takebe, MD, PhD, and Mingxia Gu, MD, PhD.

These 3D formations, grown from induced pluripotent stem cells (iPSCs), are living mini-organs that include the key cell types of full-sized organs.

Already, organoids are showing value as test platforms for preclinical drug testing and ongoing basic studies of human development. Longer term, experts at CuSTOM envision organoids grown from a patient’s own cells serving as a new method to treat disease and repair organ damage.

Read more about CuSTOM in Science.